Modern dentistry has been gradually moving toward biologically driven procedures that promote healing and reduce patient discomfort. One such innovation is Platelet, Rich Fibrin (PRF), a new second generation platelet concentrate that has transformed periodontal and oral surgical procedures.
This comprehensive manual explains what PRF is, how it works and its types, its clinical uses, benefits, limitations and future potential.
Platelet Rich Fibrin (PRF) is an autologous biomaterial obtained from the patients blood. It is rich in platelets, leukocytes, fibrin and growth factors which aid natural wound healing and tissue regeneration.
In contrast to previous platelet concentrates, the preparation of PRF does not require any anticoagulant or other chemical agent, increasing its physical and chemical safety, as well as biological compatibility.
PRF forms a three-dimensional fibrin matrix that gradually releases growth factors over time, including:
This slow release enhances:
⚠️ Timing is critical—delays can affect clot formation and quality.
PRF has become a cornerstone in regenerative periodontal therapy.
PRF significantly improves healing outcomes in oral surgical procedures.
Access to reliable PRF kits, centrifuges, and surgical consumables—available through trusted dental supply platforms like Dentalkart—helps clinicians integrate PRF protocols smoothly into daily practice.
PRF offers multiple advantages over conventional regenerative materials:
Despite its benefits, PRF has certain limitations:
Proper training and protocol standardization are essential for predictable outcomes.
| Feature | PRF | PRP |
|---|---|---|
| Anticoagulants | Not used | Required |
| Growth factor release | Slow and sustained | Rapid and short-term |
| Preparation | Simple | More complex |
| Biocompatibility | High | Moderate |
PRF is often preferred due to its simplicity and superior healing profile.
When used correctly, PRF is considered safe and highly effective.
Ongoing research is expanding PRF applications into:
PRF is expected to play an even larger role in minimally invasive regenerative dentistry.
In recent years, PRF has become a robust regenerative adjunct in various periodontal and oral surgical procedures which provides for rapid healing, enhanced regeneration and patient comfort. With its own biological advantages, ease of use and low cost, PRF is an invaluable periodontal and oral surgical tool.
With clinical protocols of various periodontal and oral procedures continuing to be refined, PRF is surely here to stay as a biologically driven dental treatment.