Plasma Fractionation Market Report | Key Players & Industry Outlook
The global plasma fractionation market was valued at $18,222 million in 2019, and is expected to reach $23,006 million by 2027, registering a CAGR of 6.2% from 2020 to 2027.
Blood is often referred to as the river of life—but beyond red and white blood cells, blood plasma contains essential proteins that play a critical role in treating a wide range of medical conditions. The process of plasma fractionation isolates and purifies these vital proteins, turning raw plasma into life-saving therapies.
The global plasma fractionation market was valued at $18,222 million in 2019, and is expected to reach $23,006 million by 2027, registering a CAGR of 6.2% from 2020 to 2027.
What is Plasma Fractionation?
Plasma fractionation is a biochemical process used to separate plasma—the liquid portion of blood—into its individual protein components. These proteins, such as albumin, immunoglobulins, and clotting factors, are then purified and processed for therapeutic use in treating diseases like immune deficiencies, hemophilia, and liver disorders.
Key Plasma-Derived Products
- Albumin Used to treat burns, shock, and hypoalbuminemia (low blood protein levels).
- Immunoglobulins (IVIG) Critical in treating immune disorders, autoimmune diseases, and certain infections.
- Coagulation Factors (Factor VIII, IX) Essential for managing bleeding disorders such as hemophilia A and B.
- Alpha-1 Antitrypsin Used in the treatment of Alpha-1 Antitrypsin Deficiency, a rare genetic disorder affecting the lungs and liver.
How Does Plasma Fractionation Work?
The process involves several key steps:
- Collection of Plasma: Obtained from healthy donors through plasmapheresis.
- Cryoprecipitation: A cold-based separation method to extract fibrinogen and clotting factors.
- Cohn Fractionation (Ethanol Precipitation): A method developed in the 1940s that uses temperature, pH, and alcohol concentration to separate plasma proteins.
- Chromatography and Filtration: Advanced techniques used for further purification of proteins.
Applications in Modern Medicine
- Immunology: Treats primary and secondary immune deficiencies.
- Neurology: IVIG is used to manage Guillain-Barré Syndrome, myasthenia gravis, and chronic inflammatory demyelinating polyneuropathy (CIDP).
- Hematology: Coagulation factors are life-saving for patients with hemophilia.
- Critical Care: Albumin helps stabilize patients undergoing surgery or trauma.
Market Trends and Growth Drivers
- Rising demand for immunoglobulin therapies due to autoimmune diseases.
- Increasing global awareness and diagnosis of rare plasma protein disorders.
- Growth in plasma donation infrastructure across North America, Europe, and Asia.
- Technological advances in purification and viral inactivation methods.
Challenges in Plasma Fractionation
- High operational costs and complex regulatory compliance.
- Supply limitations due to dependence on voluntary plasma donation.
- Cold chain logistics for transporting and storing plasma products.
Leading Companies in Plasma Fractionation
- CSL Behring
- Grifols
- Takeda (formerly Shire)
- Octapharma
- Kedrion Biopharma
Conclusion
Plasma fractionation is a cornerstone of modern therapeutic biotechnology. As the global healthcare industry expands and the need for biologics increases, this critical process continues to save millions of lives by delivering effective and reliable plasma-derived treatments.
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