G-Protein Coupled Receptors Market Driven by Demand for Targeted Therapy

The global G-protein coupled receptors (GPCRs) market was valued at USD 3.92 billion in 2024 and is expected to expand at a compound annual growth rate (CAGR) of 6.10% from 2025 to 2030. GPCRs, also referred to as seven-transmembrane receptors, bind to chemical signals and initiate cellular responses. Their proven effectiveness in identifying drug candidates with pharmaceutical relevance continues to drive their adoption in drug discovery. The increasing number of approved drugs, as well as those in clinical and preclinical stages targeting GPCRs, is boosting the demand for GPCR screening assays in drug development. Additionally, the growing use of allosteric modulators, biologics, and biased agonists aimed at GPCRs further fuels demand for related assays.

The market is also experiencing growth due to the increasing prevalence of lifestyle-related diseases such as cancer, cardiovascular, and respiratory disorders. Government investment in research and development for new drugs and therapies acts as a significant market driver. The development of numerous drugs targeting GPCRs contributes further to market expansion. However, challenges such as the high costs of cell lines and a shortage of skilled medical professionals are limiting factors that may constrain market growth to some extent.

Product Insights

The GPCR market, based on product, is segmented into cell lines and detection kits. In 2022, the cell lines segment accounted for the largest revenue share, driven by the broad availability of cell lines used in assays. Cell lines are critical in cellular impedance assays for detecting GPCR targets, supporting their substantial contribution to market revenue. Detection kits have gained traction due to their ease of use, sensitivity, and robustness in measuring activity across different signaling pathways. Innovations in label-free detection technologies, including resonance wave-guide grating and impedance-based sensors, are expected to drive further growth in this segment.

Assay Insights

By assay type, the market is segmented into cAMP functional assays, calcium functional assays, β-arrestin functional assays, radioligand binding and GTPγS functional assays, internalization assays, trafficking assays, and other assays. The cAMP functional assays segment led the market in 2024, with a revenue share of 32.5%. Cyclic Adenosine Monophosphate (cAMP) plays a pivotal role as a second messenger in GPCR signal pathways. A wide variety of reagent kits available for measuring cAMP levels significantly contributes to the segment’s dominance.

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Application Insights

Applications of GPCRs include cancer research, CNS research, metabolic research, cardiovascular research, respiratory research, and inflammation research. In 2024, the cancer research segment held the highest market share at 31.5%. GPCR activity is highly relevant in therapeutic research, especially in tumor angiogenesis and immunotherapy. These receptors are widely expressed and crucial in intercellular signaling, creating strong potential for therapeutic innovation.

Regional Insights

North America dominated the global GPCR market in 2024, accounting for a 36.9% revenue share. This dominance is attributed to strategic investments in cancer research, approval of GPCR-targeted drugs, and a robust focus on drug discovery and development. Growing awareness around healthcare and the increased use of high-throughput screening (HTS) techniques to identify biomarkers for therapeutics are additional growth factors. The proliferation of diagnostic labs and the growing use of biomarker-specific detection kits for GPCRs also support regional market expansion.

Leading Companies in the GPCR Market

Major players in the G-protein coupled receptors market include:

• Thermo Fisher Scientific Inc.
• Eurofins Scientific
• QIAGEN
• WuXi AppTec
• Promega Corporation
• Abcam plc
• Merck KGaA
• PerkinElmer Inc.
• Enzo Biochem Inc.
• BD

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