治療抵抗性高血圧市場は2024年から2034年にかけて顕著な成長傾向を示すとDelveInsightが報告 | Idorsia Pharma

The Treatment-resistant Hypertension marketplace is anticipated to expand substantially driven by growing disease prevalence and heightened awareness throughout the forecast timeline. Additionally, the introduction of numerous multi-stage Treatment-resistant Hypertension pipeline candidates will dramatically transform market dynamics.

DelveInsight's "Treatment-resistant Hypertension Market Insights, Epidemiology, and Market Forecast-2034" analysis provides comprehensive understanding of Treatment-resistant Hypertension, encompassing historical and projected epidemiology alongside market trajectories across the United States, EU5 nations (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The Treatment-resistant Hypertension market analysis encompasses emerging pharmaceuticals, current treatment methodologies, market distribution of individual therapies, and current & forecasted market valuations from 2020 to 2034. It additionally evaluates current treatment practice/algorithms, market catalysts & obstacles, and unmet medical requirements to identify optimal opportunities and evaluate underlying market potential.

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Essential Highlights from the Treatment-resistant Hypertension Market Analysis:

• The Treatment-resistant Hypertension market valuation was approximately USD 13 Million in 2023 and is projected to expand with substantial CAGR throughout the study timeframe (2020-2034)
• In May 2025, In its Q1 presentation, the organization announced its intention to release primary results from the KARDIA-3 investigation and initiate a Phase III cardiovascular outcomes trial for zilebesiran in the latter half of 2025.
• In its Q1 2025 presentation, Regeneron Pharmaceuticals disclosed the initiation of a Phase II clinical investigation to evaluate REGN5381 as a treatment for uncontrolled hypertension.
• In March 2025, Idorsia Pharmaceuticals announced that the US FDA has officially eliminated the REMS (Risk Evaluation and Mitigation Strategy) requirement for TRYVIO. Additionally, the organization is no longer obligated to execute the post-marketing requirement (PMR) involving a global descriptive investigation gathering prospective and retrospective data on women exposed to TRYVIO during pregnancy and/or breastfeeding, as this information is no longer deemed necessary.
• In February 2025, Idorsia Pharmaceuticals stated that the exclusivity arrangement made in November 2024 with an unnamed party for global rights to aprocitentan has concluded, as the party did not proceed with finalizing the agreement outlined in the nonbinding term sheet.
• Germany held the largest market share for Treatment-Resistant Hypertension among the EU4 and the UK, representing around 6%
• Several prominent organizations in the Treatment-Resistant Hypertension marketplace, including Ionis Pharmaceutical's IONIS-AGT-LRx, KBP Biosciences' ocedurenone (KBP-5074), and others, are anticipated to influence market dynamics from 2024 to 2034.
• According to DelveInsight's analysis, in 2023, there were around 16 million prevalent cases of Treatment-Resistant Hypertension across the 7MM, with nearly 10 million cases in the US. The prevalence is anticipated to rise during the forecast timeline, primarily driven by increasing global obesity rates, a key risk factor for hypertension.
• Among the EU4 and the UK, Germany had the highest prevalence of Treatment-Resistant Hypertension, with around 1 million cases, followed by Italy with approximately 960 thousand cases and Spain with nearly 780 thousand cases.
• Resistant hypertension is more prevalent in females than males. In 2023, the US had around 5 million female cases compared to 4 million male cases.
• According to our calculations, in 2023, around 1 million cases were documented in individuals aged 20-49, with prevalence increasing with age, reaching approximately 4 million cases in those aged 70 and above.
• In 2023, Japan had the highest number of treatment-resistant hypertension cases, totaling nearly 2 million, with approximately 1 million cases in females and around 860 thousand in males.
• Key Treatment-resistant Hypertension Companies: Idorsia Pharmaceuticals, Ionis Pharmaceuticals, KBP Biosciences, Quantum Genomics, CinCor Pharma, Idorsia Ltd., Chong Kun Dang , Janssen Biotech, and others
• Key Treatment-resistant Hypertension Therapies: TRYVIOTM (Aprocitentan), IONIS-AGT-LRx, Ocedurenone (KBP-5074), Firibastat, CIN-107, Aprocitentan, and others
• The Treatment-resistant Hypertension epidemiology based on gender analyzed that RHTN is more prevalent in females compared to males

Understanding Treatment-resistant Hypertension

Treatment-resistant hypertension represents high blood pressure that remains uncontrolled despite utilizing three or more antihypertensive medications, including a diuretic, at optimal doses. It increases the risk of heart disease, stroke, and kidney failure. Causes may include obesity, sleep apnea, high salt intake, or secondary conditions requiring specialized treatments like renal denervation.

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Treatment-resistant Hypertension Market Analysis

The dynamics of the Treatment-resistant Hypertension marketplace are anticipated to transform in forthcoming years owing to expected launch of emerging therapeutics and others during the forecasted period 2020-2034.

"According to the first comprehensive global analysis of trends in hypertension prevalence, detection, treatment, and control, led by Imperial College London and WHO, the number of adults aged 30-79 years with hypertension has increased from 650 million to 1.28 billion in the last thirty years."

Treatment-resistant Hypertension Epidemiology Analysis

The epidemiology section delivers insights into historical, current, and forecasted epidemiological trends across the seven major countries (7MM) from 2020 to 2034. It facilitates recognition of causes of current and forecasted trends through exploration of multiple studies and perspectives of key opinion leaders. The epidemiology segment additionally provides comprehensive analysis of diagnosed patient populations and emerging trends.

Epidemiology Segmentation: Treatment-resistant Hypertension

The Treatment-resistant Hypertension market analysis presents epidemiological evaluation for the 2020-2034 study period across the 7MM, categorized into:

• Total Prevalence of Treatment-resistant Hypertension
• Prevalent Cases of Treatment-resistant Hypertension by severity
• Gender-specific Prevalence of Treatment-resistant Hypertension
• Diagnosed Cases of Episodic and Chronic Treatment-resistant Hypertension

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Treatment-resistant Hypertension Therapeutic Uptake and Pipeline Activities

The therapeutic uptake analysis concentrates on adoption rates of potential pharmaceuticals recently introduced to the Treatment-resistant Hypertension marketplace or anticipated to launch during the evaluation period. The examination encompasses market penetration by therapeutics, patient adoption by treatment modalities, and individual drug revenue.

Furthermore, the therapeutics evaluation section facilitates understanding of pharmaceuticals demonstrating most accelerated adoption and underlying factors for maximum utilization. It also provides comparative analysis of therapeutics based on market distribution.

The analysis additionally covers Treatment-resistant Hypertension Pipeline Development Activities, delivering valuable intelligence regarding various therapeutic candidates across different developmental phases and principal companies engaged in developing targeted interventions. It further examines recent advancements including partnerships, acquisitions, mergers, licensing, patent information, and additional details for investigational therapies.

Treatment-resistant Hypertension Therapeutics and Principal Companies

• TRYVIOTM (Aprocitentan): Idorsia Pharmaceuticals
• IONIS-AGT-LRx: Ionis Pharmaceuticals
• Ocedurenone (KBP-5074): KBP Biosciences
• Firibastat: Quantum Genomics
• CIN-107: CinCor Pharma
• Aprocitentan: Idorsia Ltd / Janssen Biotech
• CKD-385-Chong Kun Dang**** 

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Treatment-resistant Hypertension Market Strengths

• Expected launch of first-in-class pharmaceuticals with novel mechanism of action like aprocitentan, CIN-107 is likely to boost Treatment-resistant Hypertension market expansion
• CKD-385 is a triple combination therapy targeting multiple pathways in hypertension: telmisartan (angiotensin II receptor blocker, ARB) blocks the renin-angiotensin system; amlodipine (calcium channel blocker, CCB) relaxes vascular smooth muscle; chlorthalidone (thiazide-like diuretic) reduces blood volume by promoting sodium and water excretion. This multi-target approach is designed to address resistant hypertension by enhancing blood pressure control through complementary mechanisms.
• A robust pipeline of pharmaceuticals with mechanism of action different from standard of care (single-pill three-drug combination) like firibastat (BAPAI molecule) is expected to offer RHTN patients alternative therapy options who are intolerant or have contraindication to spironolactone

Treatment-resistant Hypertension Market Opportunities

• Spironolactone, despite being the first-choice pharmaceutical as an add-on treatment option (PATHWAY-2 study) for Treatment-resistant Hypertension patients, there exists an urgent unmet need for alternative treatment options with improved side-effect profile, novel mechanism of action, ease of administration, etc.

Report Scope: Treatment-resistant Hypertension Market

• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
• Key Treatment-resistant Hypertension Companies: Idorsia Pharmaceuticals, Ionis Pharmaceuticals, KBP Biosciences, Quantum Genomics, CinCor Pharma, Idorsia Ltd., Janssen Biotech, and others
• Key Treatment-resistant Hypertension Therapies: TRYVIOTM (Aprocitentan), IONIS-AGT-LRx, Ocedurenone (KBP-5074), Firibastat, CIN-107, Aprocitentan, and others
• Treatment-resistant Hypertension Therapeutic Evaluation: Current marketed and emerging therapies for Treatment-resistant Hypertension
• Treatment-resistant Hypertension Market Dynamics: Market growth drivers and market obstacles for Treatment-resistant Hypertension
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Treatment-resistant Hypertension Unmet Needs, KOL perspectives, Analyst perspectives, Market Access and Reimbursement for Treatment-resistant Hypertension

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Table of Contents

1. Treatment-resistant Hypertension Market Report Introduction
2. Executive Summary for Treatment-resistant Hypertension
3. SWOT analysis of Treatment-resistant Hypertension
4. Treatment-resistant Hypertension Patient Share (%) Overview at a Glance
5. Treatment-resistant Hypertension Market Overview at a Glance
6. Treatment-resistant Hypertension Disease Background and Overview
7. Treatment-resistant Hypertension Epidemiology and Patient Population
8. Country-Specific Patient Population of Treatment-resistant Hypertension
9. Treatment-resistant Hypertension Current Treatment and Medical Practices
10. Treatment-resistant Hypertension Unmet Needs
11. Treatment-resistant Hypertension Emerging Therapies
12. Treatment-resistant Hypertension Market Outlook
13. Country-Wise Treatment-resistant Hypertension Market Analysis (2020-2034)
14. Treatment-resistant Hypertension Market Access and Reimbursement of Therapies
15. Treatment-resistant Hypertension Market Drivers
16. Treatment-resistant Hypertension Market Barriers
17. Treatment-resistant Hypertension Appendix
18. Treatment-resistant Hypertension Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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Treatment-resistant Hypertension Epidemiology https://www.delveinsight.com/report-store/resistant-hypertension-epidemiology-forecast?utm_source=apac&utm_medium=promotion&utm_campaign=kkpr

DelveInsight's 'Treatment-resistant Hypertension Epidemiology Forecast to 2034' analysis delivers comprehensive understanding of the disease, historical and forecasted Treatment-resistant Hypertension epidemiology across the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

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It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.

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